Аchievements

  • A long-term series of priority research works on studying the structure and functioning of the apparatus for biosynthesis of photosynthetic chlorophyll pigments was completed. New knowledge on the structure of the chlorophyll biosynthesis system was obtained, with its molecular-membrane model being developed. The nature of enzymes performing biosynthetic reactions was revealed, with mechanisms for regulating their activity being ascertained.
  • A scheme of light and phytohormone intracellular signaling in plants involving cyclic mononucleotides (cGMP and cAMP) and a set of secondary messengers was developed. The functional role and particular place of cGMP and cAMP in signaling pathways was specified. Biochemical parameters of the  system of cGMP and cAMP metabolism was suggested to be used as a test for a functional state of a plant cell.
  • An original insight into a protective role of light under the effect of stress factors on plant was given that was an important contribution to the adaptation theory of plants to stress, with a fluorescent method for estimating stress resistance of plants being developed for its application in breeding programs when selecting cereals accessions for thermo-and drought resistance.
  • A model of the protein structure containing a number of partially folded thermodynamically stable states was designed. It explains in a new fashion enzyme catalysis and the main point of some serious diseases (systemic amyloidoses, prion diseases, Alzheimer’s disease, Parkinson’s disease, cataract etc.) that is important for developing of a strategy for treatment and prophylaxis of the stated diseases.
  • Based on biophysical and biochemical study of transport processes in brain synaptosomes and regularities of their swelling, mechanisms of emerging serious pathology of the nervous system (brain edema) was discovered to provide new aspects in effective medical treatment of the disease.
  •  A series of priority research works on studying plant cell proteome was initiated for the first time in the Republic. Major mechanisms of the stress factor effect on the level of intracellular calcium and gene expression of phospholipase C in transgenic plant cells were revealed that is important for plant biotechnology.
  • Original findings showed the involvement of  intracellular ROS regulating protein activity in multiple drug resistance of tumor cells to were obtained to provide a basis for testing individual sensitivity to anticancer drugs.
  • The modeling of 3D-structure, conformational changes and interaction of key apoptosis  proteins tBid and Bax provided a novel basis for the design of anticancer and anti neurodegenerative diseases drugs.

In the field of directed fundamental investigations:

  • Genetic constructions for the synthesis of cecropin-mellitin antimicrobial peptides in plant cells were designed with the aim to develop plants resistant to phytopathogenic microorganisms and plant bioreactors. Lines of transformed potato plant of Belarusian cultivars synthesizing these peptides and possessing new abiotic properties were produced.
  • Experimental regulations for production of liposomal rifampycin for inhalations were worked out and the project of provisional pharmacopeial clause for the given medicinal form was developed.
  • The production schedules of “The process of preparation for bottling or drinking still water “Akvadiv” by ozone treatment method” have been developed.
  • “Guidelines on the application of the fodder additive “Chlorella suspension” for agricultural animals and birds” have been developed.
  • Fifty elaborations, which were introduced at the institutes and institutions of the Ministry of Public Health, institutes of higher education, institutions of the Ministry of Agriculture and Foodstuffs were completed, with the greater part of introductions having a social effect (introduction in practice of medical institutions and institutes of higher education in the Republic and CIS countries).

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