Team «Synapse»

Laboratory of Biophysics and Engineering of Cell

Head of the team:

S.V. Fedorovich, Ph.D.

Main research trends:

  • Regulation of free radicals formation in neuronal presynaptic endings
  • Molecular basis for nootropic drug effects
  • Molecular basis for ketogenic diet effects

Decrease in extracellular pH was shown to reduce calcium-dependent glutamate release in synaptosomes.
It was established for the first time that hypotonic swelling inhibits glutamate uptake.
The role of calcium in regulation of fusion pore at osmoinduced exocytosis was studied.
The role of lipid rafts in exocytosis regulation was ascertained.
Hypertonic shrinking was shown to induce sodium influx to synaptosomes via a special type of mechanosensitive channels.
The role of intergrins in regulation of calcium-independent neurotransmitter release was established.
It was shown, that protein ferritin, which contains iron nanoparticles, able to inhibit glutamate uptake and induces free radicals formation in synaptosomes.
It was established, that activation of glycine presynaptic receptors lead to chlorine influx with following plasma membrane depolarization.
Membrane mechanisms of nootropic drug piracetam effects were deciphered.
It is shown, that enzyme NADPH oxidase is main source of free radicals in synapse in case of glutamate ionotropic receptor activation.
It is established that extracellular but nit intracellular acidification leads to superoxide anion formation in intrasynaptosomal mitochondria.

“Synapse” group is ready to collaboration on national and international level in area of biochemistry and physiology of neuronal presynaptic endings. Collaboration can be both in form of joint project or short-term (up to 3 month) visit of members of our group to foreign lab.
Responsible person - Dr. Sergei Fedorovich (phone: 284-2252, e-mail: fedorovich@ibp.org.by )

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